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Apoptosis-resistant primary cancers

These encouraging results allowed phenoxodiol to move into clinical trials even though its mechanism of action was unclear and it is currently in Phase 111 clinical trials for drug-resistant ovarian cancer. It inhibits topo II and induces both caspase-dependent and caspase-independent apoptosis as well has having effects on the proteosome and Akt signal transduction, but recent results indicate that its primary site of action is on plasma membrane electron transport. ... [Pg.16]

See other pages where Apoptosis-resistant primary cancers is mentioned: [Pg.575]    [Pg.575]    [Pg.134]    [Pg.284]    [Pg.243]    [Pg.69]    [Pg.147]    [Pg.243]    [Pg.2136]    [Pg.1632]    [Pg.138]    [Pg.164]    [Pg.177]    [Pg.164]    [Pg.425]    [Pg.449]    [Pg.470]    [Pg.520]   
See also in sourсe #XX -- [ Pg.575 ]



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Apoptosis-resistance

Cancer apoptosis

Primary resistance

Resistance, cancer

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