Apoptosis protection

K. Dvorakova, H. Bernstein, C. Bernstein, H. Holubec and H. Garewal, Caspase-6 mediated cleavage of guanylate cyclase alpha 1 during deoxycholate-induced apoptosis protective role of the nitric oxide signalling module. Cell Biol. Toxicol, 2003, 19(6), 373. 

Caspase-3 activation induction of apoptosis apoptosis protection radical scavenger DNA intercalation release of cytochrome c Bcl-XL inhibitor activation of caspase-3 DNA fragmentation depolarization DNA intercalation spindle poison activation of caspase-3 DNA fragmentation depolarization of mitochondrial membranes, apoptotic Spindle poison activation of caspase-3 DNA fragmentation apoptotic activation of JNK/SAPK ROS production inhibition of mitochondrial electron chain Protein, DNA and RNA synthesis inhibition DNA intercalation induction of apoptosis caspase-3 activation DNA fragmentation depolarization of mitochondrial membranes Apoptosis induction... 

Gabriel, B., Sureau, F, Casselyn, M., Teissie, J., and Petit, P.X. (2003). Retroactivepathway involving mitochondria in electroloaded cytochrome c-induced apoptosis. Protective properties of Bcl-2 and Bcl-XL. Exp. Cell Res. 289, 195-210. 

Another member of the FGF family, FGF-4, protects against radiation-iaduced ceU killing and enhanced the G2 arrest when overexpressed ia a human adrenal cortical carcinoma ceU line (196). This effect is again manifested as the appearance of a shoulder on the survival curve, although neither the control nor the transfected cells undergo radiation-iaduced apoptosis. No differences ia the yield or repair of either SSBs or DSBs have been observed. 

Bursch, W. Oberhammer, F., and Schulte-Herrnann, R. (1992). Cell death by apoptosis and its protective role against di.sease. Trends Pharmacol. Set. 1.3(6), 245-251. 

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