Apoptosis and Disease

Homeostasis of cell numbers in the human body is a delicate balance between cell proliferation and apoptosis. Either deficient or excessive apoptosis may result in the development of different diseases (Table 3) (C2, T4, W4). 

Diseases associated with decreased apoptosis Diseases associated with increased apoptosis 

Immune-mediated glomerulonephritis Chemically induced diseases 

Gene-dependent tumor formation Decreased blood production 

Breast, ovary, prostate Idiopathic dilated cardiomyopathy 

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Biochim. Biophys. Acta, Special Issue Sphingolipids, Apoptosis, and Disease 2006 1758(12). 

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