Apoptogenic effects

Ghosh, P., Besra, S. E., Tripathi, G., Mitra, S., and Vedasiromoni, J. R. 2006. Cytotoxic and apoptogenic effect of tea (Camellia sinensis var. assamica) root extract (TRE) and two of its steroidal saponins TSl and TS2 on human leukemic cell lines K562 and U937 and on cells of CML and ALL patients. Leuk. Res. 30 459-68. 

Basophils comprise another group of cells actively involved in allergic inflammations. The apoptogenic effects of glucocorticoids on these cells might have implications for the mechanism of action of these drugs in allergic inflammation [72]. 

Rytdmaa, M., and Kinnunen, P.K.J., 1995, ReversibUity of the binding of cytochrome c to Uposomes. Implications for lipid-protein interactions./. B/oZ. Chem., 270 3197-3202 Salamon, Z., and ToUin, G., 1996, Surface plasmon resonance studies of complex formation between cytochrome c and bovine cytochrome c oxidase incorporated into a supported planar Upid bUayer. II. Binding of cytochrome c to oxidase-containing cardiohpin /phosphatidylcholine membranes. Biophys. J., 71 858-867 Salamon, Z., and ToUin, G., 1997, Interaction ofhorse heart cytochrome c with Upid bilayer membranes effects on redox potentials. J. Bioenerg. Biomembr. 29 211-221 Scarlett, J.L., and Murphy, M.P., 1997, Release of apoptogenic proteins from the... 

The Bcl-2 family of oncoproteins is known to play an important role in apoptosis through their ability to regulate cytochrome c release from mitochondria [11,15]. The antiapoptotic proteins Bcl-2 and Bc1-Xl prevent cytochrome c release, whereas the proapoptotic family members (e.g.. Bad, Bid, Bik, Bax) facilitate cytochrome c efflux or block the protective effects of Bcl-2 and Bc1-Xl. The mechanism involved is unclear the Bcl-2 family proteins may interact directly with the MTP (mitochondrial permeability transition) protein complex (the PTPC) or form independent ionic pores in the outer mitochondrial membrane (Fig. 3). Nonetheless, cytochrome c-depen-dent caspase-3 activation and changes in the expression or phosphorylation state of Bcl-2 family proteins are taken as indicative of mitochondria-dependent apoptotic pathways. It is important to remember that other apoptogenic proteins are also present in the mitochondrial intermembrane space, including smac/ DIABLO and flavoprotein (AIF) [10,11,60]. The release stimuli for the latter factors, which are currently being elucidated, may also involve the permeability transition or the Bcl-2 family proteins [37]. 

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