Apomyoglobin molten globule

Eliezer, D. Wright, P.E. Is apomyoglobin a molten globule Structural characterization by NMR. 

Jennings, P. A. Wright, P. E. (1993). Formation of a Molten Globule Intermediate Early in the Kinetic Folding Pathway of Apomyoglobin. Science 262, 892-896. 

This profile is identical to that observed when pH s modified. Thus, the authors concluded that total apomyoglobin unfolding occurs via the formation of a molten globule intermediate. 

Figure 3.S (lower panel). ( ), Average emission wavelength of native horse heart apomyoglobin at pH 6.0 in 10 mM bis-Tris buffer at 21 C as a function of pressure. ( ). Average emission wavelength for the molten globule state of horse heart apomyoglobin at pH 4.2.10 mM sodium acetate. 21°C. Solid lines represent fits to the data points. Source Vidugiris, G J. A. and Royer. C. A. 1998, Biophysical Journal 75, 463-470. Authorization of reprint accorded by the American Biopliysical Society...

Vidugiris, G. J. A. and Royer, C. A. 1998, Determination of the volume changes for pressure-induced transitions of apomyoglobin between the native, molten globule, and unfolded states. Biophysical Journal 75, 463-470. 

Rischel C, Thyberg P, Rigler R, et al. (1996). Time-resolved fluorescence studies of the molten globule state of apomyoglobin. J. Mol. Biol. 257 877-885. 

Tcherkasskaya O, Ptitsyn O B (1999). Direct energy transfer to study the 3D structure of non-native proteins AGH complex in the molten globule state of apomyoglobin. Protein Eng. 12 485-490. 

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