Aplidium meridianum

Aikal. indole meridianins (Aplidium meridianum (Sluitw, 1906), Polyclinidae, Ascid. from Atlantic Antarctica, depth 100m Franco 1998) psammopmmins (Psammopemma sp., Poecil. fitmi Indian Antarctica, depth 258m Butler 1992A). 

Meridianins, brominated indole alkaloids from the tunicate Aplidium meridianum, show cytotoxicity against LMM3 (murine mamarian adenocarcinoma cell line) with IC5o values of 11.4 jM for meridianin B (25), 9.3 iM for meridianin C (26), 33.9 iM for meridianin D (27), and 11.1 aM for meridianin E (28) [41]. 

An Antarctica collection of the sponge Psammopemma sp. has yielded the new 4-hydroxyindole alkaloids, psammopemmins A (1378), B (1379), and C (1380), which embody the unique 2-bromopyrimidine unit (1337). The related meridia-nins B (1381), C (1382), D (1383), E (1384), and F (1385) were found in the tunicate Aplidium meridianum collected at 100 m near the South Georgia Islands (1338,1339). These protein kinase inhibitors have been synthesized (1340). The sponge Discodermia polydiscus has afforded 6-hydroxydiscodermindole (1386) (1341). 

Hernandez Franco L, Bal de Kier Joffe E, Puricelli L, Tatian M, Seldes AM, Palermo JA (1998) Indole Alkaloids from the Tunicate Aplidium meridianum. J Nat Prod 61 1130... 

Gompel, M., Leost, M., De Kier, J. E. B., Puricelli, L., Franco, L. H., Palermo, J., Meijer, L., (2004) Meridianins, a new family of protein kinase inhibitors isolated from the asciAim Aplidium meridianum. Bioorg. Med. Chem. Lett. 14, 1703-1707. 

Meridianins A-G are brominated indole derivatives containing a 2-aminopyrimidine. They were found in Aplidium meridianum harvested by dredging at 100 m in South Georgia. These derivatives are only moderately cytotoxic but some of them are good inhibitors of protein kinases CDKl and CDK5, the most active being... 

Seldes, A.M., Rodriguez Brasco, M.F., Franco, L.H., and Palermo, JA. (2007) Identification of two meridianins from the cmde extract of the tunicate Aplidium meridianum by tandem mass spectrometry. Nat. Prod. Res., 20, 555-563. 

Fresneda, P.M., Molina, P., and Bleda, J.A. (2001) Synthesis of the indole alkaloids meridianins from the tunicate Aplidium meridianum. Tetrahedron, 57, 2355-2363. 

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