Aplastic crisis treatment

Treatment of SCD is aimed at the preventing and/or minimizing acute and chronic complications, including infection, acute chest syndrome, neurologic damage, and the various forms of sickle cell crises, including vaso-occlusive pain, splenic sequestration, and aplastic crisis. The acute and chronic complications are summarized in Tables 65-2,65-3, and 65-4. 

Most patients in aplastic crisis will recover spontaneously. Therefore, treatment is supportive. If anemia is severe or symptomatic, transfusion may be indicated. Infection with human parvovirus B19 is the most common cause of aplastic crisis. Isolate infected patients because parvovirus is highly contagious. Pregnant women should avoid contact with infected patients because midtrimester infection with parvovirus may cause hydrops fetalis and stillbirth.6,27... 

Treatment of aplastic crisis is primarily supportive. Blood transfusions may be indicated for severe or symptomatic anemia. Antibiotic therapy is not warranted because the most common etiology is viral, not bacterial, infection. 

Patients with mild cases of HS often do not need any treatment. However, these patients should be watched carefully for the development of hemolytic or aplastic crisis. Splenectomy is the treatment of choice in moderate-to-severe HS cases. In general, splenectomy is indicated in patients who are continuously anemic or who have a history of gallstone colic or repeated crises. The clinical results of splenectomy for HS are almost uniformly excellent. However, splenectomy in very young children should be postponed to later in childhood because splenectomized infants are more susceptible to serious and potentially lethal infections than are older children and adults. At the time of splenectomy, it is important to identify and remove any accessory spleen otherwise, the operation will... 

Treatment of aplastic crisis is primarily supportive. Blood transfusions may be indicated for severe or symptomatic anemia. Antibiotic therapy is not warranted because the most common etiology is viral, not bacterial, infection. Treatment options for splenic sequestration include observation alone, especially for adults because they tend to have milder episodes chronic transfusion to delay splenectomy and splenectomy after a hfe-threatening crisis, after repetitive episodes, or for chronic hypersplenism. 

Treatment of aplastic crisis is primarily supportive and most patients recover spontaneously. The patient may need blood transfusions if anemia is severe or symptomatic. Reticulotye count helps to determine if there is red cell production and the need for transfusions. The most common cause for aplastic crisis is acute infection with human parvovirus B19. Parvovirus is contagious therefore infected patients should be placed in isolation. In addition, contact with pregnant health care providers should be avoided because parvovirus infection during the midtrimester of pregnancy may result in hydrops fetalis and... 

---