Antiviral nucleotides, synthesis potential

Due to the importance of modified nucleosides that are also in the base, the development of new biocatalytic processes appUed to the synthesis of derivatives modified in the base is of great interest Adenosine deaminase (ADA) and adenylate deaminase (AMPDA) are biocatalysts that catalyze the hydrolytic deaminahon of purine nucleosides and nucleotides. Some applications of these deaminases for the preparation and transformation of compounds structurally related to nucleosides with potential antitumor and antiviral activities have been described in the last few years [8]. 

Liu, M.-C., Luo, M.-Z., Mozdziesz, D. E., et al. (2001) Synthesis of halogen-substituted 3-deazaadenosine and 3-deazagunaosine analogues as potential antitumour/antiviral agents. Nucleosides Nucleotides Nucleic Acids, 20, 1975-2000. 

Reviews have appeared on the chemistry and biological properties of aza- and deaza- nucleosides, the use of organometallic intermediates in the synthesis of nucleoside analogues, potential antiviral nucleosides, and nucleosides, nucleotides and nucleic acids. 

Herdewijn, P, Ruf, K., and Pfleiderer, W. (1991) Nucleotides Part XXXIV. Synthesis of modified oligomeric 2-5 A analogues, potential antiviral agents Helv. Chim. Acta 74, 7-23... 

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