Antiviral glycopeptide

Bleomycin is a complex of no less than 16 glycopeptide antibiotics made from the family Streptomyces verticilus, which have different R groups [88-94]. Bleomycines exhibit antitumor, antiviral, and antibacterial activity. When bound to DNA, they disturb the spiraling of both single and double strands of DNA. To a lesser degree, they inhibit RNA and protein synthesis. It is administered both intravenously and intramuscularly. 

The bleomycins are a group of glycopeptides isolated from Streptomyces verticillus as copper complexes. They have attracted much attention because, in addition to having antimicrobial and antiviral properties, they are also important in the treatment of a number of tumours, including Hodgkin s disease. Some 200 bleomycins have now been identified, although the main component of the clinical drug is bleomycin Bleomycin requires a metal ion. The Fe complex is... 

Cationic amphipathic CPs, whose nanotubes are oriented parallel to the membrane, have been found to have quite potent and selective antibiotic activity both in vitro and in vivo. The proposed mode of action for this type of peptide is based on a carpet-like mechanism, in which several nanotnbes lie parallel to the membrane surface. Antiviral activity has also been found for this type of CP and the mechanism of action proposed is based on interference of the virus fusion with the cell membrane. Interestingly, mannopeptimycins are very potent antimicrobial agents obtained from natural sources and these contain a hexacyclicpeptide that can be considered as a d,l-o -CP. The mechanism of action for these systems is not known yet, but could be based on the formation of amphipathic nanotnbes. Very recently, D,L-a-glycopeptide analogs have been designed and prepared for their potential applications as antimicrobial agents. ... 

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