Antiviral compounds steroids

Several studies were undertaken in order to investigate in more detail the nature of the antiviral compounds and their mechanisms of action. Structures of active pure compounds have been determined as PS, steroids, aminoacid derivatives, diterpenes, lipids and alkaloids. 

Steroid Antibiotics. The steroid antibiotics are a stmcturaHy diverse class of steroids that have a common biological function, ie, antibacterial, antifungal, antiviral, or antitumor activities. This group of compounds can overlap with other steroid classes Hsted above. Eusidic acid [6990-06-3] (67), helvohc acid [29400-42-8] (68), and cephalosporin [13258-72-5] (69) exemplify a set of antibacterial steroids that contain a prolanostane skeleton with an... 

Certonardosides A-E (23-27), Fig. (9) are sulfated at C-3 of the xylopyranose unit attached to C-26 of the steroidal side chain, while certonardosides F-I (28a, 28b, 29a, 29b), Fig. (10) contain a sulfate group at C-6 (a) of the steroidal aglycone. The isolated compounds were evaluated for their antiviral activity against HIV, HSV, CoxB, EMCV and VSV viruses. Certonardosides A-J were inactive within the range of non cytotoxic concentrations. Only weak antiviral activity against HSV was observed in compounds 29a and 29b and the desulfated analog of 28b. 

Arthan D, Svasti 1, Kittakoop P et al (2002) Antiviral isoflavonoid sulfate and steroidal glycosides from the fruits of Solanum torvum. Phytochemistry 59 459 63 Asres K, Bucar F (2005) Anti-HIV activity against immunodeficiency virus type 1 (HIV-I) and type II (HIV-II) of compounds isolated from the stem bark of Combretum molle. Ethiop Med 143 15-20... 

Some aminobenzoic acid diuretics containing the thiophen ring have also been studied. The syntheses and lipid-lowering properties of (203) and (204) have been described. 3-j8-(2-Thienyl-alanine-8-lysine)vasopressine has been synthesized by the solution technique. A comparison of the bioavailability of [2,5- C]thiophen after oral and rectal administration in mice has been reported. The nitro-reduction of carcinogenic 5-nitro-thiophens by rat-tissues has been studied. Thiophen-ring-containing compounds with antiradiation, antidepressant, antiparasitic, " antibacterial, - antiviral, and broncho-dilator activity have been studied. A thia-steroid, 14,15-dehydro-A-nor-3-thiaequilenin, has been synthesized. In connection with studies on the syn-... 

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