Antiviral agents, history

A 40-year-old female with a history of AIDS develops a herpes simplex keratitis of the eye. Which of the following antiviral agents should be administered in this case ... 

Antitumor drugs cisplatin as, history, 37 175-179 platinum compounds future studies, 37 206-208 resistance to, 37 192-193 second-generation, 37 178 Antiviral agents, 36 37-38 AOR, see Aldehyde oxidoreductase Aphanothece sacrum, ferredoxins, amino acid sequence, 38 225-227 Apo-calcylin, 46 455 Apo-caldodulin, 46 449-450 Apoenzyme, 22 424 Apoferritin biosynthesis, 36 457 cystalline iron core, 36 423 Fe(III)distribution, 36 458-459 Fe(II) sequestration, 36 463-464 ferroxidase centers, 36 457-458 iron core reconstruction in shell, 36 457 mineralization, 36 25 Mdssbauer spectra, 36 459-460 optical absorbance spectra, 36 418-419 subunit conformation and quaternary structure, 36 470-471... 

BaueT as made an interesting suggestion in attempting to relate virus size to the effectiveness of antiviral agents. It Is perhaps somewhat early In the history of the search for antiviral drugs to draw too many conclusions from the presently known antiviral substances. 

Any prior history of viral infections, such as chronic or recurrent herpes simplex, active dermatoses of the atopic, seborrheic or eczematous types, and medications such as topical or oral retinoids, must be reviewed. Those patients with a history of recurrent herpes infection should be treated prophylactically with oral antiviral agents, preferably Valtrex (valacyclovir), on the morning of the peel and continued for a routine course of therapy. If the patient presents on the morning of the peel with active herpetic infection in the areas to be treated, it is best to postpone the peel until complete resolution has occurred. 

The use of metals in medicine is as old as recorded human history (I). Modem successes span from what was arguably the first medicinal chemistry screening campaign by Paul Erlich to the recent development of sophisticated bioimaging agents. The therapeutic applications of metal-based drugs span virtually every disease area anticancer (Al, Ga, In, Ti, Ru, Pt, Au, Sn) antimicrobial (As, Cu, Zn, Ag, Hg, Bi) antiarthritic (Au) antipsychotic (Li) antihypertensive (Fe, Zn) antiviral (Li, Pt, Au, W, Cu) antiulcer (Bi) antacids (Al, Na, Mg, Ca) metalloenzyme mimetics (Mn, Cu, Fe) radiotherapy (e.g. Re,... 

---