Antithyroid drugs pharmacokinetics

Kampmann JP, Hansen JM. Clinical pharmacokinetics of antithyroid drugs. Clin Pharmacokinet 1981 6(6) 401-28. [Pg.342]

Note. For a review of the pharmacokinetics of antithyroid drugs, see J. P. Kampmann and J. M. Hansen, Clin. Pharmaco-kinet., 1981,6,401-428. [Pg.433]

Pharmacokinetics. Both antithyroid drugs are well absorbed (80% to 95%) from the gastrointestinal tract, with peak serum concentrations about 1 hour after ingestion. The plasma half-life ranges of PTU and MMI are 1 to 2.5 hours and 6 to 9 hours, respectively, and are not appreciably affected by thyroid status. Urinary excretion is about 35% for PTU and less than 10% for MMI. These drugs are... [Pg.1377]

Big Chemical Encyclopedia