Antisyphilitic agents

This phase saw continuous advances in chemistry and medicine. Organic chemistry was now capable of the synthesis of relatively complex targets by multistep sequences. The concept of systematically preparing a compound series and testing it for a biological effect became common, as exemplified in Ehrlich s quest for antisyphilitic agents. More and more pure natural products were identified and their structures elucidated. Synthetic mimics became a reahty. For example, amphetamines were inspired by the natnral prodnct lead, ephedrine. 

Paul Ehrlich (1854-19IS) is celebrated for his 1906 prediction that therapeutic compounds would be created in the chemist s retort. As a physician strongly interested in chemistry, he had already been awarded the Nobel Prize (1908) for his work as the founder of chemotherapy, when he made his most important discovery—the application of the polymeric organoarsenical, Salvarsan, as the first antisyphilitic agent. This finding caused an international sensation and led... 

J. G. O Shea, Two minutes with venus, two years with mercury , Mercury as an antisyphilitic chemotherapeutic agent , J. Roy. Soc. Med. London, 1990, 83, 392-395. 

Storage Store refrigerated Uses Food additive permitted in feed and drinking water of animals and/or for the treatment of food-producing animals in medicine as antisyphilitic and anthelmintic agent in organic synthesis Sodium arsenate CAS 7631-89-2 UN 1685... 

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