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3- Hydroxy-antipyrine

Antipyrine metabolism in vivo has also been demonstrated. Following extraction of media from uptake and elimination studies, TLC analysis revealed the parent compound and 4-hydroxy-antipyrine. Based upon the amount of radioactivity recovered, the metabolite may account for up to 4% of the total. This hy-droxylated metabolite is the primary oxidation product in animals studied to date (23). Further characterization of the extracts using high-pressure liquid chromatography will be done in the future. [Pg.273]

Fig. 3. Antipyrine and its metabolites NORA, norantipyrine HMA, 3-hydroxymethylantipyrine OHA, 4-hydroxyantipyrine DOHA, 4,4 -dihyroxyantipyrine HM-NORA, 3-hydroxy-methyl-norantipyrine [3,72]... Fig. 3. Antipyrine and its metabolites NORA, norantipyrine HMA, 3-hydroxymethylantipyrine OHA, 4-hydroxyantipyrine DOHA, 4,4 -dihyroxyantipyrine HM-NORA, 3-hydroxy-methyl-norantipyrine [3,72]...
Organochlorine insecticides are also well-known inducers. Treatment of rats with either DDT or chlordane, for example, will decrease hexobarbital sleeping time and offer protection from the toxic effect of warfarin. Persons exposed to DDT and lindane metabolized antipyrine twice as fast as a group not exposed, whereas those exposed to DDT alone had a reduced half-life for phenylbutazone and increased excretion of 6-hydroxy cortisol. [Pg.198]

Zur Herstellung von Antipyrin (1,5-Dime thy l-3-o.xo-2-pheny 1-2,3-dihydro-l H-pyraio ) durch Methylierung von 5-Hydroxy-3-methyl-l-phenyl-1 H-pyrazol s. Lit.254 5 2546. [Pg.708]

Ohnaus, E. E., and B. K. Park. 1979. Measurement of urinary 6-p-hydroxy cortisol excretion as an in vivo parameter in the chnical assessment of the microsomal enzyme-inducing capacity of antipyrine, phenoharhitone and rifampicin. European Journal of Clinical Pharmacology 15 139-145. [Pg.67]

Compd. with 2-Hydroxy benzoic acid (1 1) [520-07-0]. Antipyrine salicylate. Salazolon. Saldoren. Salizol. Saliphenazone. Salipyrazolon. Salipyrine Antipyretic, analgesic and antineuralgic. Mp 91-92°. [Pg.336]

Compd. with 2-Hydroxy-2-methylbutanoic acid (1 1) [5794-16-1]. Antipyrine methylethylglycolate. Astrolin Analgesic. Mp 64-65.5°. [Pg.336]

Diethylamino-4-hydroxy-5-nitroso-6-aminopyrimidine, in D-00109 4-[[4-(Diethylamino)-2-hydroxyphenyl]azo] antipyrine, see A-00392... [Pg.1001]

See other pages where 3- Hydroxy-antipyrine is mentioned: [Pg.301]    [Pg.790]    [Pg.270]    [Pg.301]    [Pg.112]    [Pg.335]    [Pg.1018]    [Pg.301]    [Pg.13]    [Pg.126]    [Pg.338]    [Pg.325]    [Pg.404]    [Pg.405]    [Pg.113]    [Pg.130]    [Pg.308]    [Pg.56]    [Pg.510]    [Pg.441]    [Pg.99]    [Pg.356]    [Pg.339]    [Pg.1028]   
See also in sourсe #XX -- [ Pg.273 ]



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