Antipsychotic drugs actions

Meltzer HY (1999) The role of serotonin in antipsychotic drug action. Neuropsychopharmacology 21 106S—115S... 

Jones, HM, Pilowsky, LS. Dopamine and antipsychotic drug action revisited. Br J Psychiatry 2002 181 271-5. 

Schwartz, J.-C., Diaz, J., Pilon, C., and Sokoloff, P. (2000) Possible implications of the dopamine D3 receptor in schizophrenia and in antipsychotic drug actions. Brain Res Rev 31 277-287. 

Breier A Serotonin, schizophrenia and antipsychotic drug action. Schizophr Res 14 187-202, 1995... 

FIGURE 11 — 2. The dopamine receptor antagonist hypothesis of antipsychotic drug action for positive symptoms of psychosis in the mesolimbic dopamine pathway is shown here. Blockade of postsynaptic dopamine 2 receptors by a dopamine 2 antagonist acting in the mesolimbic dopamine pathway is hypothesized to mediate the antipsychotic efficacy of the antipsychotic drugs and their ability to diminish or block positive symptoms. 

Electrophysiology of 5-HT2A Receptors and Relevance for Hallucinogen and Atypical Antipsychotic Drug Actions... 

History of the disease model of antipsychotic drug action... 

Matthysse S. 1973. Antipsychotic drug actions A clue to the neuropathology of schizophrenia Fed Proc 32 200-205. Mcguffin P, Tandon K, Corsico A. 2003. Linkage and association studies of schizophrenia. Curr Psychiatry Rep 5 121-127. 

Snyder, S. H., 8c Largent, B. L. (1989). Receptor mechanisms in antipsychotic drug action Focus on sigma receptors. Journal of Neuropsychiatry, 1, 7-15. 

While EPS and catalepsy in experimental animals are no longer considered to be necessary consequences of antipsychotic drug action (224,225), even the newest atypical antipsy-chotics block Dg receptors to varying degrees (12,13), and with the exception of quetiapine, can induce EPS, catalepsy, and increase serum prolactin at high doses (226-228). Thus, tests for such liabilities remain in most antipsychotic screening batteries. 

Due to the importance of dopaminergic signalling in TD development, and the suspected role of the dopamine D3 receptor (DRD3) in antipsychotic drug action, at least 20 studies have investigated... 

D receptors are unlikely to play a pivotal role in antipsychotic drug actions, perhaps because their avid affinity for endogenous DA prevents their interaction with antipsychotics. The subtle and atypical functional activities of cerebral D receptors suggest that D agonists rather than antagonists may have useful psychotropic effects, particularly in antagonizing stimulant-reward... 

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