Antioxidant defense genes

ACTIVATION OF CELLULAR SIGNALING PATHWAYS AND ANTIOXIDANT DEFENSE GENES BY ISOFLAVONES... 

Siow RC, Li FY, Rowlands DJ, de Winter P, Mann GE. 2007. Cardiovascular targets for estrogens and phytoestrogens Transcriptional regulation of nitric oxide synthase and antioxidant defense genes. Free Radio Biol Med 42 909-925. 

Carotenoids have been found to exert numerous other effects of potential importance for the RPE. Carotenoids can activate transcription pathways (Ben-Dor et al., 2005 Kalariya et al., 2008 Palozza et al., 2006 Sharoni et al., 2004) for example, by activation of the antioxidant response element (ARE) (Ben-Dor et al., 2005 Sharoni et al., 2004). The ARE is an enhancer sequence responsible for the expression of many phase-II detoxification and antioxidant genes. Thus carotenoids may upregulate cellular antioxidant defenses. 

Ozata, M. et al. (2000) Defective antioxidant defense system in patients with a human leptin gene mutation. Hormone and Metabolic Research, 32 (7), 269-272. 

Ellis JE, Yarlett N, Cole D, Humphreys MJ, Lloyd D (1994) Antioxidant defenses in the microaerophilic protozoan Trichomonas vaginalis—comparison of metronidazole-resistant and sensitive strains. Microbiol-SGM 140 2489-2494 Haggoud A, Reysset G, Azeddoug H, Sebald M (1994) Nucleotide sequence analysis of two 5-nitroimidazole resistance determinants from Bacterioides strains and of a new insertion sequence upstream of the two genes. Antimicrob Agents Chemother 38 1047-1051... 

Scapagnini G, Colombrita C, Amadio M, D Agata V, Arcelli E, Sapienza M, Quattrona A, Calabrese Y. 2006. Curcumin activates defensive genes and protects neurons against oxidative stress. Antioxid Redox Signal 8 395-403. 

Wild AC, Mulcahy RT. 2000. Regulation of gamma-glutamylcysteine synthetase subunit gene expression Insights into transcriptional control of antioxidant defenses. Free Radic Res 32 281-301. 

Tiedge, M., Lortz, S., Drinkgern, J. and Lenzen, S. (1997). Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 46, 1733-1742. 

Quercetin and rutin HepG2 cells Increased glutathione concentration, gene expression of Cu/Zn superoxide dismutase and catalase decreased malondialdehyde concentration improve antioxidant-defense system prevent cellular oxidative stress. [74] ... 

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