Antineutrophil cytoplasmic antibodies vasculitis associated with

Slot MC, Links TP, Stegeman CA, Tervaert JW. Occurrence of antineutrophil cytoplasmic antibodies and associated vasculitis in patients with hyperthyroidism treated with antithyroid drugs a long-term followup study. Arthritis Rheum 2005 53(1) 108-13. 

According to the Chapel Hill Consensus Conference on the nomenclature of systemic vasculitis (84), CSS belongs to the group of antineutrophil cytoplasmic antibodies (ANCA)-associated smaU-vessel vasculitis and is defined as an eosinophil-rich and granulomatous inflammation involving the respiratory tract, with necrotizing vasculitis affecting small- to medium-sized vessels, and associated with asthma and eosinophiha. 

Antithyroid drugs, especially propylthiouracil, can be associated with the development of antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis, often manifesting as renal disease. Atypical presentations, with pulmonary capillaritis (58) and lupus-like syndrome (59), have been described in individual cases. Furthermore, two cases of vasculitis have been associated with carbimazole, one presenting with eosinophilic granulomatous vasculitis localized to the stomach (60) and another with p-ANCA positive vasculitis causing simultaneous acute renal insufficiency and massive pulmonary hemorrhage (61). 

Gao Y, Ye H, Yu F, Guo XH, Zhao MH. Anti-myeloper-oxidase IgG subclass distribution and avidity in sera from patients with propylthiouracil-induced antineutrophil cytoplasmic antibodies associated vasculitis. Clin Immunol 2005 117(l) 87-93. 

Choi HK, Merkel PA, Walker AM, Niles JL. Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis prevalence among patients with high titers of antimyeloperoxidase antibodies. Arthritis Rheum 2000 43(2) 405-13. 

Antineutrophil cytoplasmic antibody (ANCA)-positive cutaneous leucocytoclastic vasculitis associated with antithyroid therapy in Graves disease. Australas J Dermatol 1998 39(2) 96-9. 

Keogh KA, Wylam ME, Stone JH, Specks U. Induction of remission by B lymphocyte depletion in eleven patients with refractory antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum 2005 52(l) 262-8. 

Numerous drugs have been associated with the development of vasculitis (ten Holder et al. 2002 Cuellar 2002). For example propylthiouracil is associated with cutaneous, renal, and pulmonary vascultis aUopurinol is associated with cutaneous, renal, and hepatic vasculitis hydralazine is associated with cutaneous, renal, and pulmonary vascultis and isotretinoin is associated with cutaneous, renal, pulmonary, and gastrointestinal vascultis (Cuellar 2002 ten Holder et al. 2002). Systemic polyarteritis nodosa, a vasculitis with involvement of small- and mediumsized renal arteries, has been described following minocycline use (Cuellar 2002). Patients may present with hematuria, proteinuria, reduced renal function, and hypertension. Hydralazine, propylthiouracil, aUopurinol, and peniciUamine have been implicated in the development of antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis (Choi et al. 2000). Patients exposed to these drugs... 

Four cases of new or relapsing vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA) have been described after influenza immunization [33. Several trials in patients with pre-existing autoimmune diseases failed to show an... 

Immunologic Vasculitis associated with myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA) caused by... 

Griffith ME, Lovegrove JU, Gaskin, G, et al. C-antineutrophil cytoplasmic antibody positivity in vasculitis patients is associated with the Z allele of alpha-1-antitrypsin, and P-antineutrophil cytoplasmic antibody positivity with the S allele. Nephrol Dial Transplant 1996 11 438 3. 

Choi HK, Merkel PA, Walker AM, et al. Drug-associated antineutrophil cytoplasmic antihody-positive vasculitis prevalence among patients with high titers of antimyeloperoxidase antibodies. Arthritis Rheum 2000 43(2) 405-413. lionaki S, Hogan SL, Falk RJ, et al. Association of thyroid disease and its treatment with ANCA smaU-vessel vasculitis a case control study. Nephrol Dial Transplant 2007 22(12) 3508 3515. 

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