Antimineralocorticoid activity

Hyperkalemia Yasmin contains the progestin drospirenone that has antimineralocorticoid activity, including the potential for hyperkalemia in high-risk patients, comparable to a 25 mg dose of spironolactone. Yasmin should not be used in patients with conditions that predispose to hyperkalemia. Women receiving daily, long-term treatment for chronic conditions or diseases with medications that may increase serum potassium should have their serum potassium level checked during the first treatment cycle. 

The antimineralocorticoidal activity of drospirenone is considered as a main benefit. It counteracts the salt and water retention effects of ethinylestradiol, the standard estrogen component in oral contraceptives [33]. 

The androgenic, anabolic, uterotropic, antioestrogenic, gestagenic, glucocorticoid, antiinflammatory, mineralocorticoid, antimineralocorticoid and adrenocorticoid activity of silatranes has been studied59. ... 

Azidopyrimidines. The diuretic activity of a group of 2-amino-4-azido-6-phenylpyrimidines was found to depend upon the nature of the substituent in the S position [177,178], For example, the 2-ethoxyethyl derivative had general diuretic properties like the thiazides but in addition it was more potent than spironolactone as a mineralocorticoid antagonist. The 2-propynyl derivative Figure 1.14) was also a potent antimineralocorticoid but showed no general diuretic activity. Both compounds were potent antagonists of ADH. 

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