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Antimicrobial agents/therapy aminoglycoside antibiotics

The search for useful inhaled antibiotics has been driven, in part, by a concern about the adequacy of systemic antimicrobial therapy for respiratory infections. Some agents, including aminoglycoside antibiotics, exhibit limited penetration into respiratory tract secretions. In fact, aminoglycosides may achieve sputum concentrations that are 12% of related serum concentrations. In addition, cystic fibrosis patients are often colonized with mucoid strains of Pseudomonas aeruginosa. This phenotype is associated with a further reduction in penetration of antibiotics. [Pg.487]

Integration of both pharmacokinetic and pharmacodynamic properties of an agent is important when choosing antimicrobial therapy to ensure efficacy and prevent resistance. Antibiotics may demonstrate concentration-dependent (aminoglycosides and fluoroquinolones) or time-depen-dent (/l-1 acta ms) bactericidal effects. [Pg.392]

The use of antimicrobial therapies through aerosolization avoids many of the toxicities associated with systemic therapy with aminoglycosides or polypeptide agents. However, the risk for promoting antibiotic resistance is a concern. The emergence of highly resistant organisms has been reported... [Pg.496]


See other pages where Antimicrobial agents/therapy aminoglycoside antibiotics is mentioned: [Pg.1123]    [Pg.1134]    [Pg.12]    [Pg.526]    [Pg.1438]    [Pg.1987]    [Pg.2199]    [Pg.99]    [Pg.1279]    [Pg.1933]    [Pg.2225]    [Pg.1226]   
See also in sourсe #XX -- [ Pg.28 , Pg.29 , Pg.30 , Pg.31 , Pg.32 ]




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Aminoglycosides

Antibiotic agents

Antibiotic therapy

Antibiotics agents/therapy

Antibiotics antibiotic therapy

Antibiotics antimicrobial

Antibiotics: aminoglycosides

Antimicrobial therapy

Antimicrobial therapy aminoglycosides

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