Antimalaria agents

In a few cases, the option of preparing tailor-made CSPs for a particular racemic structure has been applied. For example, we prepared on an empirical basis a particular polysaccharide-based CSP for the separation of the enantiomers of the enantiomers of the LTD4 antagonist iralukast and of the antimalaria agent benflumethol [87]. These two racemic drugs were only poorly resolved on the commercially available polysacharide-based phases whereas an excellent separation was obtained on the carbamate derivative of cellulose obtained from cellulose and 3-chloro-4-methylphe-nylisocyanate. The prepared CSP was also used to perform pharmacokinetic studies. 

Note Though I have been unable to find any clinical trial data for the use of eucalyptus as an antimalaria agent, it has been found specific (and powerful) for that microbial disease in several in vitro studies. 

There remains an urgent need for new effective antiparasitic agents, an area of drug development that has languished because of poor economic return. The spread of resistance to chloroquine (an antimalaria treatment) is one reason for attention to be paid to this area, as well as the sheer numbers of people affected. Antimony compounds (43) and (44) (Figure 20) are used to treat... 

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