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Antihypertensives ganglion-blocking agents

C. Trimethaphan is a ganglionic blocking agent that will lower blood pressure very rapidly. Hydralazine is a vasodilator hydrochlorothiazide and spironolactone are diuretics and methyldopa is a sympatholytic acting in the central nervous system. All of these drugs are used clinically as antihypertensive agents. None work as rapidly as trimethaphan. Clinically, however, either nitroprusside or clonidine is used much more commonly than trimethaphan in this situation. [Pg.147]

Pentam pentamidine, pentamethonium bromide [ban, inn] (pentamethonium iodide [ban]) is a quaternary ammonium compound that acts as a ganglion blocking agent and was formerly used as an antihypertensive. pentamethonium iodide pentamethonium bromide. [Pg.216]

It possesses both diuretie and antihypertensive actions. It is often used as an adjunct to other antihypertensive drugs, such as reserpine and the ganglionic blocking agents. [Pg.450]

Ganglion c Blocking Agents - A number of cyclic hindered amines substituted on the a-carbon with ethynyl, vinyl and alkyl groups have been synthesized and their antihypertensive properties compared with a corresponding series of open chain compounds. It was found that the open chain compounds were... [Pg.50]

In conclusion, the incorporation of an acetylenic moiety into a benzylamine structure conferred completely novel biochemical and therapeutic properties on an otherwise inert phenylalkylamine. Outstanding in this respect are the potent MAO-inhibitory, antihypertensive, and antidepressant effects of this new drug. The potent autonomic side effects normally encountered with the ganglionic blocking type antihypertensive agents are much less pronounced with this drug and a definite advance has been scored toward achieving selectivity of action. [Pg.127]

Hexamethonium (Fig. 16.28) is a quaternary ammonium agent. It was the first successful antihypertensive treatment. However, its side effects led to discontinuation of its use. It is thought to exert its action by blocking the ion channel rather than the acetylcholine active site. Blocking the ganglionic nicotinic receptor will stop the... [Pg.333]


See other pages where Antihypertensives ganglion-blocking agents is mentioned: [Pg.327]    [Pg.146]    [Pg.233]    [Pg.235]    [Pg.43]    [Pg.97]    [Pg.140]    [Pg.172]    [Pg.216]    [Pg.281]    [Pg.281]    [Pg.282]    [Pg.72]    [Pg.98]    [Pg.427]    [Pg.156]    [Pg.73]    [Pg.74]    [Pg.40]    [Pg.40]   
See also in sourсe #XX -- [ Pg.323 ]




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Antihypertensive agent

Blocking agents

Ganglion blocking agent

Ganglionic

Ganglionic blocking agent

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