Antihistamines neuroleptic drugs

Kristiansen and Blom [56] examined various types of phenothiazines for antibacterial effect on 61 Gram-positive and Gram- negative bacterial strains in vitro the investigated phenothiazines were two neuroleptic drugs, fluphenazine and chlorpromazine, and an antihistaminic drug, prometha-... 

Drugs with a CNS depressant effect (antihistamines, hypnotics, sedatives, narcotic analgesics, alcohol, etc.) will have an increase in effect caused by interaction with neuroleptic drugs. 

Benzatropine and ethylbenzatropine are particularly likely to interact additively with other drugs with both anticholinergic and antihistaminic activity, such as neuroleptic drugs complications such as hyperpyrexia, coma, and toxic psychosis have been reported several times when such combinations were used (626-628). 

The potentiation of sedative effects from benzodiazepines when combined with centrally acting drugs with antihistamine properties (for example first-generation antihistamines, tricyclic antidepressants, and neuroleptic drugs) can pose problems (143). Antihistamines that do not have central actions do not interact with benzodiazepines as in the case of mizolastine and lorazepam (144), ebastine and diazepam (145), and terfenadine and diazepam (143). 

The effect of acetylcholinesterase inhibitors can be reduced by drugs with anticholinergic effects, such as antihistamines or neuroleptic drugs (12). 

Since dyskinesia can occur after withdrawal of phenothiazine neuroleptic drugs, it is not unlikely that the same problem may follow termination of prolonged antihistamine therapy. 

The extensive and long-term use of phenothiazine derivatives might result in unwanted or side effects. Moreover, their application as antihistaminic and/or neuroleptic drugs in the therapy of schizophrenia, organic psychoses... 

Central Motor restlessness, progressing to maniacal agitation, psychic disturbances, disorientation, and hallucinations. Elderly subjects are more sensitive to such central effects, in this context, the diversity of drugs producing atropine-like side effects should be borne in mind e.g., tricyclic antidepressants, neuroleptics, antihistamines, antiarrhythmics, antiparkinsonian agents. 

Thiepanes of the general structure (256) include the drugs octoclothepin (antischizophrenic), chlorotepin (antiinflammatory), trifluthepin (antidepressant), methiothepin (antihistamine) and oxyprothepin (neuroleptic). The slightly modified 10,11-dihy-drodibenzo[6,/]thiepins (257 dithiadene) and (258) have a similar range of pharmacological activities. 

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