Antihistamines allergic disorder treatment

Simons FE Hi-antihistamines more relevant than ever in the treatment of allergic disorders. J Allergy Clin Immunol 2003 112 42-52. 63... 

Antihistamines conventionally refer to antagonists of the H -receptor. and have wide applications in the treatment of allergic disorders, and in anaphylaxis. 

Eleven of 15 workers who were exposed to HMDI showed allergic and nonallergic skin reactions. Six suffered from vertigo with or without headaches, and four showed obstructive ventilatory disorders, tachycardia, and hypotension (EGG normal). All were treated with oral antihistamines and local steroid application. The signs of the intoxication disappeared after 10-14 days of treatment. There was no difference in the clinical syndrome between the atopic and the nonatopic workers. 

When used for the treatment of colds and allergic upper airways disorders, antihistamines (alone or in combination with decongestants) can reduce mucociliary motility in the middle ear, thus contributing to the development of otitis media (41). 

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