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Antiherpetic drug acyclovir

The potent antiherpetic drug 9-[(2-hydroxyethoxy)methyl]guanine (acyclovir, Zovirax) (78NAT583) possesses potent antiviral activity in cells infected with herpes simplex virus type 1 (HSV-1), but it is essentially nontoxic to uninfected host cells. The discovery of acyclovir (ACV) has... [Pg.392]

The synthesis and biological activity of the new acyclic heterodinucleotide (113) that consists of both an antiherpetic (acyclovir) and an antiretroviral (2-(phosphonomethoxy)propyl-adenine) drug linked by a pyrophosphate bridge were reported. The heterodinucleotide (113), prepared from the reaction of a morpholidate derivative of PMPA and the tributylammonium salt of acyclovir monophosphate in the presence of pyridine, behaved as a pro-drug in macrophages. Anti-HIV and anti-HSV activity of this compound were demonstrated in HIV-lfia-L and HSV-1-infected macrophages. ... [Pg.191]

Acyclovir Wellcome lactam antibiotics) DNA polymerase inhibitor (antiherpetic) 1975 1974 Breakthrough drug Breakthrough drug... [Pg.138]

See other pages where Antiherpetic drug acyclovir is mentioned: [Pg.223]    [Pg.8]    [Pg.740]    [Pg.223]    [Pg.8]    [Pg.740]    [Pg.130]    [Pg.698]    [Pg.111]    [Pg.694]    [Pg.400]    [Pg.474]    [Pg.2002]   
See also in sourсe #XX -- [ Pg.30 , Pg.400 ]

See also in sourсe #XX -- [ Pg.400 ]



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Acyclovir

Antiherpetic drug

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