Antiglaucoma preparations

Antiglaucoma Preparations and Miotics Sympathomimetics in glaucoma therapy (clonidine, brimonidine)... 

Contrary to instillation of standard eyedrops, unilateral application of emulsified pilocarpine induced a biphasic effect in (he contralateral eye, presumably due to systemic absorption. The authors concluded tha(, in spite of (his drawback, (he pilocarpine submicrometer emulsion might serve as a long acting antiglaucoma preparation, requiring a single daily instillation. In another... 

A reaction of this type was used to prepare an intermediate in the synthesis of a natural compound with antiglaucoma activity.143... 

Uses miotic and antiglaucoma agent used in ophthalmic preparations... 

Another example of the industrial use of methyl ( )-p-hydroxybutyrate is Zeneca s synthesis of an intermediate for MK-0507 (trade name Trusopt Fig. 7), an antiglaucoma drug developed by Merck [65]. In this synthesis, a ketosulfone derivative is prepared from the tosylate of methyl (/ )-P-hydroxybutyrate, which is as3nnmetrically reduced to a (45,dS)-hydroxysulfone derivative, a key intermediate for MK-0507, by a microorganism. 

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