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Antigenic features of immunoglobulins

Antigenic Features of Immunoglobulins B. Heavy-Chain Variable Region Determinants... [Pg.109]

Monoclonal antibody therapy (MAT) makes use of all the major features of the immune response. It involves vaccination/ immunization, albeit in experimental animals, to induce the desired specific immune response. It exploits the high specificity, selectivity, and affinity of the antibody CDR toward the target antigen to be recognized, highlighted, inactivated, or eliminated, using the characteristics of the Fc portion of an immunoglobulin to facilitate the means for such inactivation or elimination and for selection of appropriate effector mechanisms. Finally, MAT represents a modern form of serotherapy, in which parenteral administration of whole serum or Ig preparations has been replaced by recombinant antibody molecules of a defined specificity. [Pg.371]

A. Tramontano and A. M. Lesk. Common features of the conformations of antigen binding loops in immunoglobulins and application to modeling loop conformations. Proteins 73 231-245 (1992). [Pg.100]

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