Antifungal preparations indications

Athlete s foot, tinea pedis, is a condition caused by a fungus. Management of athlete s foot lies with the use of antifungal preparations such as clotrimazole (an imidazole antifungal) and tolnaftate. Salicylic acid is a keratolytic agent indicated for use in treatment of corns, calluses and warts. 

A variety of otic preparations have been reviewed here, including indications, side effects, and limitations. The ideal cerumenolytic compound has not yet been developed, nor has a cerumen replacement product. Antiseptics enjoy wide application but are limited when used in the presence of a perforated tympanic membrane. Available antifungal medications appear to be adequate for the treatment of otomycosis, although none have been approved as otic preparations. The limitations of the otic antimicrobial drops have been stated, including the potential both for organism resistance and for ototoxicity. The recent introduction of Floxin and Cipro HC products make available better otic antimicrobial drops for treatment... 

Isoflavonoids also have been reported to have physiological activity in animal and human studies. Besides acting as an estro n mimic, it was reported that the isoflavones found in soybean seeds possess antihemolytic, antifungal, tumorsuppressing, and serum cholesterol-lowering effects. In addition, both epidemiological and dietary-intervention studies indicate that when isoflavones in soybean seeds and in subsequent protein products prepared from the seeds are part of the human dietary intake, those products provide many significant health benefits. - ... 

D-Rlbose has been used to prepare the enol ether (15) (Scheme 7) which was then converted to (-)-isoavenaclolide (16), an antifungal mould metabolite, with the key step being the indicated free-radical process. 

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