Antifungal preparations imidazole

Athlete s foot, tinea pedis, is a condition caused by a fungus. Management of athlete s foot lies with the use of antifungal preparations such as clotrimazole (an imidazole antifungal) and tolnaftate. Salicylic acid is a keratolytic agent indicated for use in treatment of corns, calluses and warts. 

Ethonam (99), an imidazole derivative with a very different substitution pattern, is also reported to possess antifungal activity. To prepare it, alkylation of aminotetralin 94 with methylchloro-acetate gives the glycine derivative 95. Heating with formic acid then affords the amide 96 this compound is then reacted with ethyl formate to yield hydroxymethylene ester 97. Reaction with isothio-cyanic acid gives the imidazole-2-thiol 98. (The... 

Daktacort cream is a trade name for a preparation containing miconazole (imidazole antifungal) and hydrocortisone (corticosteroid). 

Apart from imidazole derivative e.g. metronidazole, tinidazole, nimorazole etc. and other agents such as hydroxy quinolines, iodine preparation (povidoneiodine) and antifungal antibiotics e.g. clotrimazole (used mainly as vaginal pessaries), there are some other compounds which are mainly used in the treatment of trypanosomiasis. They are ... 

R. Di Santo, et al., J. Med. Chem., 48, 5140-5153 (2005). This product is one of a series of compounds prepared for evaluation as an antifungal agent. It is prepared by alkylation of an in situ generated imidazole with an alcohol. The reaction is done with N,N -carbonyldiimidazole (CDI). Draw the product. 

PEG is a liquid polymer that possesses several green properties suitable for use as an alternative solvent for organic transformations [99]. Moreover, its miscibility with water, ease of recyclability, and the ability to act as phase-transfer catalyst has prompted its use as an eco-friendly solvent. A series of imidazole-containing 1,5-benzodiazepines 145 have been prepared from condensation of appropriate chalcones and OPD (Scheme 30). Some of the prepared compounds were found to possess antibacterial and antifungal properties [100]. 

---