Antifungal drugs introduction

Therapy for infection Ronan McMullan and Amit Bedi Introduction Antibacterial agents Other antibacterial drugs Antifungal drugs Antiviral therapy INTRODUCTION... 

Nystatin was discovered in 1950 and exhibits the same mode of action as amphotericin B but tends to be of lower solubility, which has restricted its use to the treatment of topical infections. While nystatin was effective for the treatment of conditions such as oral and vaginal candidosis its use has been overtaken by the introduction of azole antifungal drugs. 

Following an introduction to therapeutic strategies and commonly encountered microbes, this chapter discusses antibacterial, antiviral, antifungal, and antiparasitic drugs. 

Besides its extensive application in industrial processes, e.g., ROMP and ADMET, the alkene metathesis has been applied to drug discovery and peptide synthesis. Examples include the synthesis of antifungal lactone (-)-gloeosporone, the cross-metathesis of the amino acid homoallylglycine, the introduction of carbon-carbon cross-linkages into... 

Mastrolorenzo, A., Rusconi, S., Scozzafava, A. et al. 2007. Inhibitors of HIV-1 protease Current state of the art 10 years after their introduction. From antiretroviral drugs to antifungal, antibacterial and antitumor agents based on aspartic protease inhibitors. Curr. Med Chem. 14 2734—2748. 

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