Antifungal azoles, names

Antifungal azoles, names, 270-27It Aphelenchus avenae. ecdysteroids, 214 Apis melllfera. effect of sterols on brood production, 183 Artemisia absinthium, sesquiterpene Inhibitor production, 104 Ascaris. sterol biosynthesis, 202-203 Ascarls suum, ecdysteroids, 214 Aspergillus nldulans, studies of sterol inhibitors, 276-277 Aspergillus nlger. studies of fatty acids, 222,223... 

Structural basis of human CYP51 inhibition by antifungal azoles. J Mol Biol 397 1067-1078 Lamb DC, Kelly DE, Waterman MR, Stromstedt 2762. M, Rozman D, Kelly SL (1999) Characteristics of the heterologously expressed human lanos-terol 14a-demethylase (other names P45014DM, 2763. 

The UK manufacturers advise eaution if quetiapine is given with mac-rolides and azole antifungals, and suggest that lower quetiapine doses should be considered. The US manufaeturers also advise eaution, and specifically name itraconazole and fluconazole, erythromycin and protease inhibitors, all of which are inhibitors of CYP3A4. 

The catalytic asymmetric addition of thioacetic acid to nitroalkene 450 has been applied to the first enantioselec-tive synthesis of (/f)-sulconazole 453 in four steps (Scheme 46.52). Sulconazole is a class of azole antifiingals known to act by inhibition of the fungal cell CYP51 lano-sterol demethylase. Sulconazole nitrate solution, under the trade name of Exelderm (Ranbaxy USA, Princeton, NJ), is a broad-spectrum antifungal agent intended for topical apphcation to treat skin infection such as athlete s foot and sun fungus. 

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