Antifungal agents combination therapy with

Treatment is typically initiated based on symptoms, rather than on microscopic evaluation. Since several species can cause tinea infections, the choice of antifungal agent is not always clear. For infections accompanied by inflammation, combination therapy with a topical steroid can be considered. 

When amphotericin B is combined with flucytosine, a smaller dose of amphotericin B can be employed because of the in vitro and in vivo synergy between the two antifungal agents. Resistance develops to flucytosine in up to 30% of patients treated with flucytosine alone, limiting its usefulness as monotherapy. Combination therapy with amphotericin B and flucytosine will sterilize the CSF within... 

Therapy of fungal arthritis consists of amphotericin B in combination with surgical debridement. Azole antifungal agents including itraconazole, fluconazole, voriconazole, and posaconazole, are promising in the therapy of fungal arthritis. 

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