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Antiepileptics carbamazepine

Other agents are also used for the treatment of manic-depressive disorders based on preliminary clinical results (177). The antiepileptic carbamazepine [298-46-4] has been reported in some clinical studies to be therapeutically beneficial in mild-to-moderate manic depression. Carbamazepine treatment is used especially in bipolar patients intolerant to lithium or nonresponders. A majority of Hthium-resistant, rapidly cycling manic-depressive patients were reported in one study to improve on carbamazepine (178). Carbamazepine blocks noradrenaline reuptake and inhibits noradrenaline exocytosis. The main adverse events are those found commonly with antiepileptics, ie, vigilance problems, nystagmus, ataxia, and anemia, in addition to nausea, diarrhea, or constipation. Carbamazepine can be used in combination with lithium. Several clinical studies report that the calcium channel blocker verapamil [52-53-9] registered for angina pectoris and supraventricular arrhythmias, may also be effective in the treatment of acute mania. Its use as a mood stabilizer may be unrelated to its calcium-blocking properties. Verapamil also decreases the activity of several neurotransmitters. Severe manic depression is often treated with antipsychotics or benzodiazepine anxiolytics. [Pg.233]

Derivatives of 11 //-dibenz[6,e]azepine (morphanthridines) and 5/2-dibenz[Z>,/]azepine are valuable, commercial pharmaceutical products. The most important derivatives are the antidepressant, Depramine (16),30 the antiepileptic, Carbamazepin (17),62 the hypnotic agents Perlapine (18),63-64 and its 2-fluoro derivative (Fluperlapine),65 and Opipramol (19), an antidepressant and antipsychotic agent.66... [Pg.211]

Recently, with the development of more advanced and sensitive analytical methods, studies on the fate of pharmaceuticals in WWTP have taken into account the analysis of pharmaceuticals sorbed into sludge (Table 4, and references therein). The antiseptics triclocarban and triclosan and the antibiotic ofloxacin have been reported in sludge at concentrations up to 441, 133, and 58 mg kgdw-1, respectively. Compounds such as the anti-inflammatory ibuprofen, the antiepileptic carbamazepine and the antidepressant fluoxetine have also frequently been reported though at lower levels (11,6 and 3 mg kgdw 1, respectively), whereas the (3-blockers were found at low... [Pg.92]

LITHIUM ANTIEPILEPTICS-CARBAMAZEPINE, PHENYTOIN t risk of neurotoxicity Uncertain this may occur with normal lithium blood levels Warn patients and carers to watch for drowsiness, ataxia and tremor... [Pg.157]

PACLITAXEL 1. ANTIBIOTICS-rifampicin 2. ANTIDEPRESSANTS-St John s wort 3. ANTIEPILEPTICS -carbamazepine, phenobarbital, phenytoin 1 plasma concentration of paclitaxel and 1 efficacy of paclitaxel Due to induction of hepatic metabolism of paclitaxel by the CYP isoenzymes Monitor for clinical efficacy and need to T dose if inadequate response is due to interaction... [Pg.326]

PLATINUM COMPOUNDS ANTIEPILEPTICS -CARBAMAZEPINE, PHENYTOIN, VALPROIC ACID l plasma concentrations of antiepileptic, which t risk of seizures Due to impaired absorption of antiepileptic Monitor closely for seizure activity and warn patients and carers. Need to adjust dosage using parameters such as blood levels to ensure therapeutic levels... [Pg.332]

PROCARBAZINE ANTIEPILEPTICS-CARBAMAZEPINE, PHENOBARBITAL PHENYTOIN, VALPROIC ACID T risk of hypersensitivity reactions in patients with brain tumours Strong correlation between the therapeutic antiepileptic level and the hypersensitivity reactions Consider using non-enzyme-inducing agents... [Pg.336]

TAMOXIFEN ANTIEPILEPTICS -CARBAMAZEPINE, PHENYTOIN, PHENOBARBITAL i plasma concentrations of tamoxifen and risk of inadequate therapeutic response Due to induction of metabolism of tamoxifen by the CYP3A isoenzymes by phenytoin Avoid concurrent use if possible. Otherwise monitor for clinical efficacy of tamoxifen by t dose of tamoxifen... [Pg.349]

CORTICOSTEROIDS ANTIEPILEPTICS -CARBAMAZEPINE, PHENYTOIN, PHENOBARBITAL 1 plasma concentrations of corticosteroids and risk of poor or inadequate therapeutic response, which would be undesirable if used for e.g. cerebral oedema Due to induction of the hepatic metabolism by the CYP3A4 isoenzymes Closely monitor therapeutic response - clinically, by ophthalmoscopy and radiologically - and t dose of corticosteroids for desired therapeutic effect... [Pg.370]

MEBENDAZOLE ANTIEPILEPTICS -CARBAMAZEPINE, PHENYTOIN 1 mebendazole levels Induction of metabolism Watch for poor response to mebendazole... [Pg.593]

CIMETIDINE, FAMOTIDINE, RANITIDINE ANTIEPILEPTICS -CARBAMAZEPINE PHENYTOIN t plasma concentrations of phenytoin and risk of adverse effects, including phenytoin toxicity, bone marrow depression and skin reactions Inhibition of metabolism via CYP2C9 and CYP2C19 Use alternative acid suppression, e.g. ranitidine, or warn the patient that the effects last 1 week. Consider monitoring carbamazepine levels and adjust dose as necessary... [Pg.644]

Several drugs, for example the oral contraceptive pill, viloxazine, thiabendazole, aminoglutethimide, antiepileptics (carbamazepine, phenytoin, barbiturates) and the antibiotic rifampicin decrease plasma concentrations of theophylline. [Pg.770]

Acute hepatocellular necrosis. This reaction varies from a transient disturbance of liver function tests to acute hepatitis. It can be induced by several drugs including general anaesthetics (halothane), antiepileptics (carbamazepine, phenytoin, sodium valproate, phenobarbital), antidepressants (MAO inhibitors), antiinflammatory drugs (indomethacin, ibuprofen), antimicrobials (isoniazid, sulphonamides, nitrofurantoin) and cardiovascular drugs (methyldopa, hydralazine). [Pg.654]

STPs are found to be the major contributor of pharmaceuticals in the Ebro River water. Compounds more frequently detected in the Ebro River basin were analgesics (diclofenac, naproxen, ibuprofen), lipid regulators (gemfibrozil, bezafibrate), antibiotics (azythromycin, trimethoprim, erythromycin, sulfamethoxazole), the antiepileptic carbamazepine, the antihistaminic ranitidine, and the 6-blockers atenolol and sotalol, which are the ones of major consumption in Spain as well as the ones excreted at higher percentages as parent drugs. Concentrations detected in both waste and surface waters are from 100 to 1000 times lower than the levels reported to cause acute toxicity. However, with respect to chronic effects, for some of the most ubiquitous compounds the margin of safety is narrow. As a wide spectrum of pharmaceuticals has been detected in natural waters, effects of mixtures should also be taken into account. [Pg.297]

APREPITANT ANTIEPILEPTICS- CARBAMAZEPINE, PHENOBARBITAL, PHENYTOIN i aprepitant levels Induction of CYP3A4-mediated metabolism of aprepitant Watch for poor response to aprepitant... [Pg.280]

IRINOTECAN 1. ANTIBIOTICS-rifampicin 2. ANTICANCER AND IMMUNOMODULATING DRUGS - dexamethasone 3. ANTIDEPRESSANTS-St John s wort 4. ANTIEPILEPTICS-carbamazepine, phenobarbital, phenytoin i plasma concentrations of Irinotecan and risk of i therapeutic efficacy. The effects may last for 3 weeks after discontinuation of CYP-inducer therapy Due to induction of CYP3A4-mediated metabolism of irinotecan Avoid concomitant use when ever possible if not, t dose of irinotecan by 50%... [Pg.392]

CASPOFUNGIN ANTIEPILEPTICS- CARBAMAZEPINE, PHENYTOIN J- caspofungin levels, with risk of therapeutic failure Induction of caspofungin metabolism t dose of caspofungin to 70 mg daily... [Pg.653]

DANAZOL ANTIEPILEPTICS- CARBAMAZEPINE t plasma concentrations of carbamazepine, with risk of toxic effects Inhibition of carbamazepine metabolism Watch for toxic effects of carbamazepine... [Pg.755]

GRAPEFRUIT JUICE ANTIEPILEPTICS- CARBAMAZEPINE t in plasma concentrations of carbamazepine (AUC11,4-fold, maximum concentration t), which is of clinical significance because of the narrow therapeutic index of carbamazepine thus, toxic effects are likely, t efficacy and t adverse effects Grapefruit juice irreversibly inhibits intestinal CYP3A4. Transport via P-gp and MRP-2 efflux pumps is also inhibited Monitor fort side-effects/toxicity and check carbamazepine levels weekly. If levels or control of fits are variable, remove grapefruit and grapefruit juice from the diet... [Pg.803]

The metabolisim of paracetamol is increased in patients taking enzyme-inducing antiepileptics (carbamazepine, phenytoin, pheno-barbital, primidone). Isolated reports describe unexpected hepatotoxicity in patients taking phenobarbital, phenytoin, or carbamazepine after taking paracetamol. Valproate does not appear to affect paracetamol metabolism. [Pg.191]

There is some evidence that the enzyme-inducing antiepileptics (carbamazepine, phenobarbital, phenytoin and primidone) may modestly reduce levetiracetam levels, but this is not thought to be clinically relevant. Levetiracetam does not usually alter the levels of these antiepileptics. However, some studies have found modestly raised phenytoin levels, and cases of possible carbamazepine toxicity have also been reported. There appears to be no pharmacokinetic interaction between levetiracetam and gabapentin, lamotrigine, or valproate. [Pg.543]

Tiagabine piasma ieveis are reduced by enzyme-inducing antiepileptics (carbamazepine, phenytoin, phenobarbital and primi-... [Pg.573]

See other pages where Antiepileptics carbamazepine is mentioned: [Pg.150]    [Pg.219]    [Pg.222]    [Pg.178]    [Pg.60]    [Pg.282]    [Pg.215]    [Pg.216]    [Pg.217]    [Pg.218]    [Pg.290]    [Pg.292]    [Pg.293]    [Pg.294]    [Pg.295]    [Pg.385]    [Pg.419]    [Pg.46]    [Pg.523]    [Pg.544]    [Pg.610]   
See also in sourсe #XX -- [ Pg.207 , Pg.304 , Pg.306 , Pg.309 ]



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