Antidepressants administration routes

Other orthopramides have been shown to be resistant to in vivo hydrolysis. Thus, the gastrokinetic drug cisapride (4.80) was not hydrolyzed after oral administration to dogs and humans [51]. Similarly, sulpiride (4.81), an antidepressant and antipsychotic drug, did not undergo hydrolysis in humans and laboratory animals. These compounds are metabolized by other routes, and hydrolysis of the amide bond, when it occurs at all, is only a minor pathway. 

Abuse potential of a drug is related to its capacity to produce immediate satisfaction, which may be a feature of the drug itself (amfetamine and heroin give rapid effect while tricyclic antidepressants do not) and its route of administration in descending order inhalation/i.v. i.m./s.c. oral. 

Information on routes of administration, dose calculations, antidepressants, stimulants, muscle relaxants, antiepileptic drugs, and diuretics... 

A preliminary clinical paper reported that high doses of L-tryptophan produced an antidepressive response similar to that elicited by imipramine.48 imipramine caused a decrease in the rate of disappearance of norepinephrine from the rat brain after a single intraperitoneal dose, but not after long-term administration by this route. This result may explain the delayed onset of action of the tricyclic antidepressives, and suggests that thyroid hormone or pharmacological agents that increase the turnover of norepinephrine in the brain, if... 

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