Second-generation anticoagulants

Antagonist hydroxyl function, triazole fungicides, 181 Antibacterial agents, 88 Anticoagulants, second generation, toxicity, 47... 

Superwarfarins Second-generation anticoagulant rodenticides related to warfarin. 

Second generation anticoagulant rodenticide which also blocks prothrombin formation... 

Borst, G.H., Cormotte, G.H. (2002). Shortfalls using second-generation anticoagulant rodenticides. J. Zoo Wildl. Med. 33(1) 85. 

DuVall, M.D., Murphy, M.J., Ray, A.C., Reagor, J.C. (1989). Case studies on second-generation anticoagulant rodenticide toxicities in non-target species. J. Vet. Diagn. Invest. 1(1) 66-8. 

Greaves, J.H., Shepherd, D.S., Quy, R. (1982). Field trials of second-generation anticoagulants against difenacoum-resistant Norway rat populations. J. Hyg. (Lond.) 89(2) 295-301. 

Lund, M. (1984). Resistance to the second-generation anticoagulant rodenticides. Proceedings of the 11th Vertebral Pesticide Conference, Sacramento, CA, p. 89. 

Brodifacoum is a member of the second-generation anticoagulant rodenticides known as superwarfarins (27). This compound and others like it (e.g., bromadiolone and difenacoum) were developed to combat rodent resistance to warfarin (27). 

Brodifacoum [3-(3-(4 -bromobiphenyl-4-yl)-l,2,3,4-tetrahydro naphth-l-yl)-4-hydroxycoumarin] is one of the newer and more potent second-generation anticoagulant rodenticides. It was first introduced in 1977 by Sorex Ltd. of London, and then developed by the Imperial Chemicals Incorporated (ICI) Plant Protection Division (Chalermchaikit et al., 1993). 

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