Neomycin Anticoagulants, oral

NEOMYCIN ANTICOAGULANTS - ORAL Elevated prothrombin times and T risk of bleeding The mechanism is not fully understood however, it is thought that neomycin may 1 number of vitamin K-producing bacteria in the gastrointestinal tract and/or that the absorption of vitamin K may be 1 by the neomycin The INR should be monitored in all patients starting or stopping neomycin therapy. Patients more at risk are those with an inadequate diet... 

Drugs that inhibit platelet function (e.g., aspirin) or produce thrombocytopenia increase the risk of bleeding when heparin is administered. Oral anticoagulants and heparin produce synergistic effects. Many basic drugs precipitate in the presence of the highly acidic heparin (e.g., antihistamines, quinidine, quinine, phenothiazines, tetracycline, gentamicin, neomycin). 

Drug Interactions Contraceptive effects are decreased when "the pill" is taken with ANTIDIOTICS (ampicillin, isoniazid, neomycin, pen V, rifampin, sulfonamides, tetracycline) or CNS AGENTS (barbiturates, benzodiazepines, phenytoin). Contraceptives increase the effects of corticosteroids and worsen side effects of tricyclic antidepressants. Oral contraceptives decrease the effectiveness of oral anticoagulants, anticonvulsants, and oral hypoglycemic agents. 

---