Anticoagulant rodenticides analytical methods

A number of analytical methods have been reported for detecting anticoagulant rodenticides in various matrices. Early fluorimetric methods were used to detect warfarin in serum (Com and Berberich, 1967 Fasco et al, 1977 Hanna et al, 1978 Reiser and Martin, 1974 Lee et al, 1981 Lewis etfl/., 1970 O Reilly e/n/., 1962 Vesell and Shively, 1974 Welling et al, 1970) and GLC for warfarin (Mildha et al, 1974). 

Indeed, after appropriate sample preparation, standards and samples can be spotted or sprayed onto the same plate, thereby providing a rapid and cost-effective analytical procedure to evaluate all sampling times. If an ultraviolet (UV) scanner is used, it is also possible to determine the amount of substance for each sample. Furthermore, the UV scanner sensitivity may be adapted specifically to analyze highly concentrated samples and poorly concentrated ones on the same plate, provided the calibration curve includes the values. As an example. Fig. 1 presents some kinetic data obtained for vitamin K, which is used as an antidote in dogs suffering from anticoagulant rodenticide poisoning [2]. The method was developed on Ci8-coated silica gel plates. Elution was based... 

A number of analytical methods have been reported for detecting anticoagulant rodenticides in various matrices. Early fluorimetric methods were used to detect warfarin in serum (O Reilly et al., 1962 Corn and Berberich,... 

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