Anticholinergic effects memory impairment

Anticholinergic side effects (e.g., dry mouth, blurred vision, constipation, urinary retention, tachycardia, memory impairment, and delirium) and sedation are more likely to occur with the tertiary amine TCAs than with the secondary amine TCAs. 

Anticholinergic (ACh) side effects include impaired memory, dry mouth, constipation, tachycardia, blurred vision, inhibition of ejaculation, and... 

Blockade of cholinergic receptors, which can result in a variety of peripheral anticholinergic adverse effects and memory impairment... 

Although atropine and scopolamine share many properties, an important difference is the easier entry of scopolamine into the CNS. Typical doses of atropine (0.2-2 mg) have minimal central effects, while larger doses can produce a constellation of responses collectively termed the central anticholinergic syndrome. At intermediate doses (2-10 mg), memory and concentration may be impaired, and the patient may be drowsy. If doses of 10 mg or more are used, the patient may exhibit confusion, excitement, hallucinations, ataxia, asyn-ergia, and possibly coma. 

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