Anticholinergic drugs Stimulant effects

Hundreds of patients have received huge doses of atropine and scopolamine (up to 250 mg), sometimes given three times a week for up to 4 mo, and this form of therapy continues in Eastern Europe today. A chronic behavioral syndrome of toxicity appears unlikely, and single or even multiple exposures to the anticholinergic drugs used In the volunteers, frequently at low doses, are deemed Insufficient to stimulate a persistent toxic syndrome. Of course. Individual susceptibility to acute effects, which may trigger a long-term effect, cannot be excluded. 

Procyclidine is an anticholinergic drug (1). The usual oral dose, which lies between 20 and 30 mg/day, is likely to produce only mild anticholinergic adverse effects, but involuntary movements, with chewing and sucking, have been described in some patients (SEDA-1, 120). Even small doses have produced toxic confusional states when procyclidine was combined with phenothiazines for schizophrenia. Procyclidine is more hkely to produce sedation than stimulation. 

Meclizine is an anticholinergic drug that acts on the CNS to decrease vestibular stimulation and depress labyrinthine activity. It is indicated in the prevention and treatment of nausea, vomiting, and dizziness of motion sickness possibly as effective treatment for vertigo of vestibular dysfunction origin. 

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