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Anticancer drugs interleukins

Grande C, Firvida JL, Navas V, Casal J. 2006. Interleukin-2 for the treatment of solid tumors other than melanoma and renal cell carcinoma. Anticancer Drugs. 17 1-12. [Pg.56]

Another approach is the inhibition of the TNF-converting enzyme (TACE), which converts proTNF into its mature, proinflammatory form. Also, numerous inhibitors of P38 and Erk-MAP kinases have been synthesized and some have reached the clinical trial stage. MAP-p38 kinase occupies a central role in the signaling network responsible for the up-regulation of proinflammatory cytokines like interleukin 1 and TNFa. The pathway of Erk-MAP kinase is often up-regulated in human tumors and as such represents an attractive target for the development of anticancer drugs. ... [Pg.98]

ANTICANCER AND IMMUNOMODULATING DRUGS OTHER IMMUNOMODULATING DRUGS Interleukin-2 (aldesleukin)... [Pg.453]

Sato M, Sasaki M, Hojo H (1993) Induction of metallothionein synthesis by oxidative stress and possible role in acute phase response. In Suzuki KT, Imura N, Kimura M (eds) Metallothionein III. Birkhauser, Basel, pp 125-140 Satoh M, Tsuchiya T, Kumada Y, Naganuma A, Imura N (1993) Protection against lethal toxicity of various anticancer drugs by preinduction of metallothionein synthesis in mice. J Trace Element Exp Med 6 41-44 Schroeder JJ, Cousins RJ (1990) Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures. Proc Natl Acad Sci USA 87 3137-3141... [Pg.136]


See other pages where Anticancer drugs interleukins is mentioned: [Pg.410]    [Pg.274]    [Pg.410]    [Pg.166]    [Pg.660]    [Pg.72]    [Pg.80]    [Pg.191]    [Pg.604]    [Pg.361]    [Pg.70]    [Pg.403]    [Pg.1320]    [Pg.756]    [Pg.92]    [Pg.56]    [Pg.202]   
See also in sourсe #XX -- [ Pg.512 , Pg.523 ]




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