Anticancer compounds titanocene

Anticancer compounds (continued) ruthenium arene compounds, 12, 451 selective estrogen receptor modulators, 12, 446 titanocenes, 12, 450... 

As mentioned in the introduction, metallocene-type complexes based on the early transition metals were evaluated as anticancer compounds shortly after the discovery of cisplatin. While the biological activity of each of the metallocene dihalides is unique, titanocene dichloride 7 has been the subject of a number of studies and even entered clinical evaluation, although evaluation was discontinued (not due to its anti-proliferative properties), principally due to formulation problems, despite showing superior activity to certain cancers than other established drugs. This class of compound continues to be modified and studied for anticancer activity, for example, the titanocene-type derivative of tamoxifen 1, described above, and other developments described below. 

Fig. 5 Selected examples of anticancer compounds with metallocene fragments a titanocene dichloride b ferrocenyl oestrogen mimic complexes - see Chapter by Jaouen (this volume), for more examples c a ferrocenyl gold complex...

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