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Ellipticine anticancer activity

Since the isolation of ellipticine and its congeners from natural sources, and the initial discovery of their anticancer activity in various experimental and human... [Pg.89]

Shi LM, Myers TG, Fan Y et al. Mining the National Cancer Institute Anticancer Drug Discovery Database Cluster analysis of ellipticine analogs with p53-inverse and central nervous system-selective patterns of activity. Mol Pharmacol 1998 53 241-51. [Pg.462]

Ellipticine Arrest G2/M phase of the cell cycle, release of cyt-c and AIF, activation of caspases, A m dissipation, increase intracellular ROS levels, activation of ERK and JNK. RL95-2 human endometrial cancer cells Alkaloid isolated from Apocyanaceae plants with several anticancer mechanism reported topoisomerase II inhibition and formation of DNA adducts [131]. [94]... [Pg.11]


See other pages where Ellipticine anticancer activity is mentioned: [Pg.71]    [Pg.324]    [Pg.38]    [Pg.329]    [Pg.27]    [Pg.424]    [Pg.71]    [Pg.475]    [Pg.296]    [Pg.27]    [Pg.424]    [Pg.682]    [Pg.71]    [Pg.22]    [Pg.47]    [Pg.858]    [Pg.160]    [Pg.5]    [Pg.55]    [Pg.877]    [Pg.687]    [Pg.741]    [Pg.1200]    [Pg.1216]    [Pg.694]    [Pg.37]    [Pg.311]    [Pg.740]    [Pg.999]    [Pg.1179]    [Pg.9]   
See also in sourсe #XX -- [ Pg.89 , Pg.90 , Pg.182 , Pg.183 ]




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