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Antibody specificity, maturation

Assays such as this that use polyclonal mitogens for activation may not be as sensitive as specific antigen-driven systems (Luster et al., 1988). In addition, suppression of the mitogen response does not always correlate with the PFC response. Since mitogenesis represents only a small aspect of B-cell function and maturation, this endpoint is not sensitive to early events that may affect activation, or later events that may affect differentiation of B cells into antibody-secreting cells (Klaus and Hawrylowicz, 1984). [Pg.566]

Shortly after formation of coated vesicles, the clathrin coat is removed and the vesicles are referred to as endosomes. Endosomes are roughly 300 400 nm in diameter when fully mature. Antibodies to earlier and late endosomes are available from antibodies-online GmbH, Aachen, Germany (http //www.antikoerper-online. de/). Early endosomal antigen 1 (EEA1) is a 162 kDa membrane-bound protein component specific to the early endosomes and is essential for their fusion with early endocytic vesicles for subsequent redistribution of extracellular compounds to... [Pg.89]

See other pages where Antibody specificity, maturation is mentioned: [Pg.261]    [Pg.267]    [Pg.256]    [Pg.3]    [Pg.13]    [Pg.234]    [Pg.306]    [Pg.650]    [Pg.992]    [Pg.119]    [Pg.125]    [Pg.346]    [Pg.159]    [Pg.227]    [Pg.65]    [Pg.498]    [Pg.305]    [Pg.91]    [Pg.244]    [Pg.1404]    [Pg.9]    [Pg.494]    [Pg.123]    [Pg.284]    [Pg.643]    [Pg.240]    [Pg.285]    [Pg.119]    [Pg.251]    [Pg.1380]    [Pg.137]    [Pg.103]    [Pg.238]    [Pg.242]    [Pg.645]    [Pg.313]    [Pg.493]    [Pg.576]    [Pg.273]    [Pg.62]    [Pg.93]    [Pg.181]    [Pg.449]    [Pg.30]    [Pg.64]    [Pg.437]   
See also in sourсe #XX -- [ Pg.159 , Pg.160 ]



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Antibodies specificity

Antibodies, specific

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