Antibody-ribosome-mRNA ARM complexes

He, M., and Taussig, M. J., (1997). Antibody-ribosome-mRNA (ARM) complexes as efficient selection particles for in vitro display and evolution of antibody combining sites. Nucleic Adds Res. 25, 5132—5134. 

Ribosome Display. This cell-free display system uses the same principle as the phage-display systems in bacteria. The phenotype and genotype of a peptide are linked together and, therefore, can be simultaneously selected based on the function of the peptide. However, the linkage is a physical one in that the genetic material is covalently linked to its encoded product in the formation of an antibody-ribosome-mRNA (ARM) complex through in vitro transcription/translation [59]. 

Figure 1 Ribosome display cycle for antibody selection (ARM display). ARM = antibody ribosome-mRNA complex.

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