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Antibody-mediated neutralization chemokines

Inhibition of inflammatory cytokines (Fig. 2) Humanized monoclonal anti-TNF antibodies (Infliximab (Remicade ), Adalimumab (Humira )) bind with high selectivity to human TNF-a and neutralize its activity. Thereby, infliximab decreases the effects of enhanced TNF levels during inflammatory disease such as production of proteases, chemokines, adhesion molecules, cyclooxygenase products (prostaglandins), and proinflammatory molecules such as interleukin-1 and -6. The antibodies may also recognize membrane-bound TNF-a on lymphocytes and other immune cells. These cells may subsequently become apoptotic or are eliminated via Fc-receptor-mediated phagocytosis. [Pg.412]

See other pages where Antibody-mediated neutralization chemokines is mentioned: [Pg.154]    [Pg.72]    [Pg.295]    [Pg.11]    [Pg.36]    [Pg.351]    [Pg.353]    [Pg.321]    [Pg.322]    [Pg.323]    [Pg.337]    [Pg.341]    [Pg.387]    [Pg.28]    [Pg.353]    [Pg.190]    [Pg.10]    [Pg.148]    [Pg.251]    [Pg.303]    [Pg.57]    [Pg.340]    [Pg.243]    [Pg.325]    [Pg.348]    [Pg.54]    [Pg.143]    [Pg.153]    [Pg.164]    [Pg.19]    [Pg.194]    [Pg.260]    [Pg.261]   
See also in sourсe #XX -- [ Pg.72 ]



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