Antibodies discovery, phage display

Affinity selection is by far the most important application of phage display (for practical reviews, see [4, 5]). Libraries of phage-displayed peptides are now commonly used to select peptides that bind to receptors or enzymes of therapeutic interest. The technology is also very powerful for the discovery of new monoclonal antibodies from collections of phages displayed single chain Fv or Fab fragments. 

Ladner, R.C., Sato, A.K., Gorzelany, J., and de Souza, M., 2004. Phage display-derived peptides as therapeutic alternatives to antibodies. Drug Discovery Today, 9, pp. 525-529. 

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