Antibiotics - tetracyclines

Dmg distribution into tissue reservoirs depends on the physicochemical properties of the dmg. Tissue reservoirs include fat, bone, and the principal body organs. Access of dmgs to these reservoirs depends on partition coefficient, charge or degree of ionization at physiological pH, and extent of protein binding. Thus, lipophilic molecules accumulate in fat reservoirs and this accumulation can alter considerably both the duration and the concentration—response curves of dmg action. Some dmgs may accumulate selectively in defined tissues, for example, the tetracycline antibiotics in bone (see Antibiotics,tetracyclines). 

Amphotericin B. Amphotericin B (3), an important polyene antibiotic, is administered almost exclusively via the intravenous route and is therefore discussed in more detail under the systemic antimycotics. The vaginal tablets contain 50 mg amphotericin B, and 100 mg tetracycline base per tablet (see also Antibiotics, tetracyclines). The tablets for oral use contain 50 mg amphotericin B, 250 mg tetracycline base, and 125 mg sodium hexametaphosphate. A combination ointment contains 1 mg fludrocortisone acetate, 2.5 mg neomycin, 0.25 mg gramicidin, and 1 g plastibase in addition to 30 mg amphotericin B (see also Antibiotics, peptides). 

Brodersen DE, Clemons WM, Carter AP et al (2000) The structural basis for the action of the antibiotics tetracycline, pactamycin and hygromycin B on the 30S ribosomal subunit. Cell 103 1143-1154... 

This reaction can be applied to substituted benzocyclobutenes. For example, the reaction has been used to form an array of five linear rings containing most of the functionality for the antibiotic tetracycline. 

Still among the most frequently prescribed drugs, the antibiotic tetracyclines have decreased in popularity recently due to development of bacterial resistance in the clinic. The search for improved agents goes on. 

Antibiotics Tetracycline LiP from Flask scale 50 mg L-1 >99% after 30 min, only in [26]... 

Antibiotics Tetracyclines Charm II 6600/7600 Charm Sciences Inc. http //www.charm.com... 

Antibiotics, 11 867. See also Macrolide antibiotics Polyether antibiotics Tetracyclines... 

One or more antibiotics tetracycline, streptomycin, gentamicin, chloramphenicol, quinolone A vaccine seems to be effective... 

Gu C, Karthikeyan KG (2008) Sorption of the antibiotic tetracycline to humic-mineral complexes. J Environ Qual 37 704-711... 

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