Antibiotics reaction with nucleic acids

Quinone methides have been shown to be important intermediates in chemical synthesis,1 2 in lignin biosynthesis,3 and in the activity of antitumor and antibiotic agents.4 They react with many biologically relevant nucleophiles including alcohols,1 thiols,5-7 nucleic acids,8-10 proteins,6 11 and phosphodiesters.12 The reaction of nucleophiles with ortho- and /iara-quinone methides is pH dependent and can occur via either acid-catalyzed or uncatalyzed pathways.13-17 The electron transfer chemistry that is typical of the related quinones does not appear to play a role in the nucleophilic reactivity of QMs.18... 

Adverse drug reactions can be induced by drugs of very diverse nature, including antibiotics, low molecular chemicals, or nucleic acids. Such reactions can be induced directly or indirectly in various ways. Direct effects on the immune system can result in immunosuppression, or in immune stimulation such as with some nucleic acid therapeutics siRNAs or AS ODNs. In contrast, indirect immune effects are caused by immune responses to a chemical or to selfdeterminants altered by a chemical such as with low molecular small molecules. 

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