Antibiotics Evans aldol reaction

In the study of biosynthesis of polyketide antibiotics. Cane and Luo applied the Evans aldol reaction to prepare a key intermediate 41 from aldehyde 40 and Evans reagent 20. °... 

In a study on the biosynthesis of the polyether antibiotic lasalocid A, a syn-selective Evans aldol reaction of 83 with methacrolein gave 84 in 95% isolated yield. In the total synthesis of the antitumor sesquiterpenoid (+)-eremantholide A, an Evans aldol reaction was used to deliver a single syn-... 

The reliability, scope, and ease of execution of the aldol addition reactions with acyl oxazolidinones have resulted in their extensive use in complex molecule synthesis. In Evans synthesis of the macrolide antibiotic cytovaricin (69), oxazolidinone aldol methodology was utilized to control the installation of eight stereogenic centers (Scheme 4.7) [53]. 

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