Antibiotics antituberculosis drugs

The antituberculosis drugs viz. isoniazid, rifampin, and ethambutol have been duly treated under Newer Drugs for Newer Diseases -Chapter-30 whereas, streptomycin under Antibiotics -Chapter-25, and hence pyrazinamide shall be discussed as under ... 

Background Tuberculosis (TB) and leprosy are perhaps the best known mycobacterial diseases. The development of antibiotics in the past fifty years has changed the therapy of tuberculosis from strict bed rest for a year or longer to oral antibiotics taken as an outpatient. In addition, antituberculosis drugs are now taken prophytactically to prevent fulminant TB in patients who may have been infected with mycobacteria. 

Iron-containing pharmaceutical compounds are used and developed as anticancer and antibiotic drugs as well as for treatment of iron deficiency. For instance, Mossbauer spectroscopy was used for studying iron complexes with anticancer antibiotics such as anthracyclines [148], adenosine derivatives [149], and cyclin-dependent kinase inhibitors [ISO]. Sharaby analyzed iron complexes of hexachlorocyclodiphosph(V)azanes of sulfaguanidine (H4L) with antimicrobial activity [151]. Recently, some iron-containing complexes with antituberculosis activity were studied using Mossbauer spectroscopy [152,153]. 

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