Antibiotic rotation resistance

Gruson, D. Hilbert, G. Vargas, F. Valentino, R. Bebear, C Allery, A. Bebear, C. Gbikpi-Benissan, G. Cardinaud, J.P. Rotation and restricted use of antibiotics in a medical intensive care unit. Impact on the incidence of ventilator-associated pneumonia caused by antibiotic-resistant gramnegative bacteria. Am. J. Respir. Crit. Care Med. 2000, 162 (3 Pt. 1), 837 843. 

Intramuscular injections of antibiotics should be given deep into the muscle and sites should be rotated if more than one injection is prescribed. Stop orders and the need for renewal orders will depend on the healthcare agency policy. However, it is common that antibiotic orders are for 72 hours only until the results of a culture and sensitivity test can be obtained. Antibiotic prescriptions are usually not renewed. This is an effort to limit the opportunity for the microbial to become resistant to the medication. 

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